Ontology highlight
ABSTRACT:
SUBMITTER: Arawaka S
PROVIDER: S-EPMC6674490 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Arawaka Shigeki S Wada Manabu M Goto Saori S Karube Hiroki H Sakamoto Masahiro M Ren Chang-Hong CH Koyama Shingo S Nagasawa Hikaru H Kimura Hideki H Kawanami Toru T Kurita Keiji K Tajima Katsushi K Daimon Makoto M Baba Masanori M Kido Takashi T Saino Sachiko S Goto Kaoru K Asao Hironobu H Kitanaka Chihumi C Takashita Emi E Hongo Seiji S Nakamura Takao T Kayama Takamasa T Suzuki Yoshihiro Y Kobayashi Kazuo K Katagiri Tadashi T Kurokawa Katsuro K Kurimura Masayuki M Toyoshima Itaru I Niizato Kazuhiro K Tsuchiya Kuniaki K Iwatsubo Takeshi T Muramatsu Masaaki M Matsumine Hiroto H Kato Takeo T
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060901 36
Sporadic Parkinson's disease (sPD) is a common neurodegenerative disorder, characterized by selective degeneration of dopaminergic neurons in the substantia nigra. Although the pathogenesis of the disease remains undetermined, phosphorylation of alpha-synuclein and its oligomer formation seem to play a key role. However, the protein kinase(s) involved in the phosphorylation in the pathogenesis of sPD has not been identified. Here, we found that G-protein-coupled receptor kinase 5 (GRK5) accumula ...[more]