Ontology highlight
ABSTRACT:
SUBMITTER: Gambardella J
PROVIDER: S-EPMC7544666 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gambardella Jessica J Sorriento Daniela D Bova Maria M Rusciano Mariarosaria M Loffredo Stefania S Wang Xujun X Petraroli Angelica A Carucci Laura L Mormile Ilaria I Oliveti Marco M Bruno Morelli Marco M Fiordelisi Antonella A Spadaro Giuseppe G Campiglia Pietro P Sala Marina M Trimarco Bruno B Iaccarino Guido G Santulli Gaetano G Ciccarelli Michele M
Hypertension (Dallas, Tex. : 1979) 20200908 5
Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of the endothelium in angioedema. However, the molecular mechanisms underlying these responses have not been investigated. BK receptors are Gq-protein-coupled receptors phosphorylated by GRK2 (G protein-coupled receptor kinase 2) with a hitherto unknown biological and pathophysiological significance. In the present study, we sought to identify the functional role of GRK2 in angioedema through the regulation ...[more]