Ontology highlight
ABSTRACT:
SUBMITTER: Lin JZ
PROVIDER: S-EPMC6675460 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lin Jean Z JZ Rabhi Nabil N Farmer Stephen R SR
Cell reports 20180501 7
Adipose tissue fibrosis is associated with inflammation and insulin resistance in human obesity. In particular, visceral fat fibrosis is correlated with hyperlipidemia and ectopic fat accumulation. Myocardin-related transcription factor A (MRTFA) is an important coactivator that mediates the transcription of extracellular matrix and other fibrogenic genes. Here, we examine the role of MRTFA in the development of adipose tissue fibrosis and identify a signaling pathway that regulates the fate of ...[more]