Ontology highlight
ABSTRACT:
SUBMITTER: Bogathy E
PROVIDER: S-EPMC6675864 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Bogáthy Emese E Papp Noémi N Vas Szilvia S Bagdy György G Tóthfalusi László L
Frontiers in pharmacology 20190726
<b>Study Objectives:</b> (a) To describe the microarchitecture of wakefulness and sleep following administrations of 5- and 10-mg/kg AM-251 in rats. (b) To develop a new statistical method to follow bout-to-bout dynamics. <b>Method:</b> Wistar rats (n = 6) had been equipped with electroencephalography (EEG) and electromyography (EMG) electrodes. Following their recovery and habituation after the surgery, the animals were injected with vehicle and 5- and 10-mg/kg AM-251 intraperitoneally and EEG, ...[more]