Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC6676478 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Cell reports 20190501 6
Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins. Although the CDC45 MCM GINS (CMG) structure implies that interstrand crosslinks (ICLs) are absolute blocks to replisomes, recent studies indicate that cells can restart DNA synthesis on the side of the ICL distal to the initial encounter. Here, we report that restart requires ATR and is promoted ...[more]