Ontology highlight
ABSTRACT:
SUBMITTER: Takata K
PROVIDER: S-EPMC3778836 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Takata Kei-ichi K Reh Shelley S Tomida Junya J Person Maria D MD Wood Richard D RD
Nature communications 20130101
Mammalian HELQ is a 3'-5' DNA helicase with strand displacement activity. Here we show that HELQ participates in a pathway of resistance to DNA interstrand crosslinks (ICLs). Genetic disruption of HELQ in human cells enhances cellular sensitivity and chromosome radial formation by the ICL-inducing agent mitomycin C (MMC). A significant fraction of MMC sensitivity is independent of the Fanconi anaemia pathway. Sister chromatid exchange frequency and sensitivity to UV radiation or topoisomerase in ...[more]