Ontology highlight
ABSTRACT:
SUBMITTER: Johnston AD
PROVIDER: S-EPMC6677801 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature communications 20190802 1
Functional variants in the genome are usually identified by their association with local gene expression, DNA methylation or chromatin states. DNA sequence motif analysis and chromatin immunoprecipitation studies have provided indirect support for the hypothesis that functional variants alter transcription factor binding to exert their effects. In this study, we provide direct evidence that functional variants can alter transcription factor binding. We identify a multifunctional variant within t ...[more]