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Platelets Are Critical Key Players in Sepsis.

ABSTRACT: Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet-pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.

SUBMITTER: Vardon-Bounes F

PROVIDER: S-EPMC6679237 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Platelets Are Critical Key Players in Sepsis.

Vardon-Bounes Fanny F Ruiz Stéphanie S Gratacap Marie-Pierre MP Garcia Cédric C Payrastre Bernard B Minville Vincent V

International journal of molecular sciences 20190716 14

Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet-pathogens interactions. The c ...[more]

PMID: 31315248

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