Ontology highlight
ABSTRACT:
SUBMITTER: Fu Z
PROVIDER: S-EPMC6679941 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Fu Zheng Z Ye Jian J Dean Joseph W JW Bostick John W JW Weinberg Samuel E SE Xiong Lifeng L Oliff Kristen N KN Chen Zongming E ZE Avram Dorina D Chandel Navdeep S NS Zhou Liang L
Cell reports 20190701 1
Regulatory T cells (Tregs) are pivotal for immune suppression. Cellular metabolism is important for Treg homeostasis and function. However, the exact role of mitochondrial respiration in Tregs remains elusive. Mitochondrial transcription factor A (Tfam) is essential for mitochondrial respiration and controls mitochondrial DNA replication, transcription, and packaging. Here, we show that genetic ablation of Tfam in Tregs impairs Treg maintenance in non-lymphoid tissues in the steady state and in ...[more]