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Direct Radiofluorination of Arene C-H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant.

ABSTRACT: Herein, we describe an organic photoredox system for direct arene C-H radiofluorination, using a peroxide oxidizing agent and LEDs as the light source. In conjunction with an optimized photocatalyst and a microtubing reactor, this system is applicable to a range of electron-rich aromatics and heteroaromatics. We also demonstrate the feasibility of C-H radiofluorination without an azeotropic drying step, which greatly simplifies the workflow of the labeling process.

SUBMITTER: Wang L

PROVIDER: S-EPMC7774802 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Direct arene C-H fluorination with 18F- via organic photoredox catalysis.

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Direct Acylation of C(sp(3))-H Bonds Enabled by Nickel and Photoredox Catalysis.

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