CK-2127107 amplifies skeletal muscle response to nerve activation in humans.
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ABSTRACT:
SUBMITTER: Andrews JA
PROVIDER: S-EPMC6681065 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
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CK-2127107 amplifies skeletal muscle response to nerve activation in humans.
Andrews Jinsy A JA Miller Timothy M TM Vijayakumar Vipin V Stoltz Randall R James Joyce K JK Meng Lisa L Wolff Andrew A AA Malik Fady I FI
Muscle & nerve 20171211 5
<h4>Introduction</h4>Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-2127107 (CK-107), a next-generation fast skeletal muscle troponin activator (FSTA), in healthy participants. We tested the hypothesis that CK-107 would amplify the force-frequency response of muscle in humans.<h4>Methods</h4>To assess the force-frequency response, participants received single doses of CK-107 and placebo in a randomized, double-blind, 4-period, crossover study. The forc ...[more]
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