Genetics-driven discovery of novel regulators of lipid metabolism.

ABSTRACT:

Purpose of review

Residual cardiovascular disease risk and increasing metabolic syndrome risk underscores a need for novel therapeutics targeting lipid metabolism in humans. Unbiased human genetic screens have proven powerful in identifying novel genomic loci, and this review discusses recent developments in such discovery.

Recent findings

Recent human genome-wide association studies have been completed in incredibly large, detailed cohorts, allowing for the identification of more than 300 genomic loci that participate in the regulation of plasma lipid metabolism. However, the discovery of these loci has greatly outpaced the elucidation of the underlying functional mechanisms. The identification of novel roles for long noncoding RNAs, such as CHROME, LeXis, and MeXis, in lip

SUBMITTER: Ha EE 

PROVIDER: S-EPMC6681899 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature