Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6682659 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhang Yuan Y Zhao Yanfang Y Zhang Lei L Yu Wanpeng W Wang Yu Y Chang Wenguang W
Frontiers in cellular neuroscience 20190730
The pathological features of Alzheimer's disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. Recent observations have suggested the possibility of an association between AD and cellular prion protein (PrP <sup><i>C</i></sup> ) levels. PrP <sup><i>C</i></sup> is a high affinity receptor for oligomeric Aβ and is important for Aβ- ...[more]