Ontology highlight
ABSTRACT:
SUBMITTER: Park H
PROVIDER: S-EPMC6684442 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190704 33
Pd<sup>II</sup> -catalyzed C(sp<sup>3</sup> )-H olefination of weakly coordinating native amides is reported. Three major drawbacks of previous C(sp<sup>3</sup> )-H olefination protocols, 1) in situ cyclization of products, 2) incompatibility with α-H-containing substrates, and 3) installation of exogenous directing groups, are addressed by harnessing the carbonyl coordination ability of amides to direct C(sp<sup>3</sup> )-H activation. The method enables direct C(sp<sup>3</sup> )-H functionaliz ...[more]