Pd(II)-catalyzed olefination of sp3 C-H bonds.

ABSTRACT: The first Pd(II)-catalyzed sp(3) C-H olefination reaction has been developed using N-arylamide directing groups. Following olefination, the resulting intermediates were found to undergo rapid 1,4-addition to give the corresponding gamma-lactams. Notably, this method was effective with substrates containing alpha-hydrogen atoms and could be applied to effect methylene C-H olefination of cyclopropane substrates.

SUBMITTER: Wasa M 

PROVIDER: S-EPMC2841429 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature