Ontology highlight
ABSTRACT:
SUBMITTER: Krupkova O
PROVIDER: S-EPMC6686831 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Krupkova Olga O Cambria Elena E Besse Lenka L Besse Andrej A Bowles Robert R Wuertz-Kozak Karin K
JOR spine 20180315 1
The CRISPR/Cas9 system has emerged as a powerful tool for mammalian genome engineering. In basic and translational intervertebral disc (IVD) research, this technique has remarkable potential to answer fundamental questions on pathway interactions, to simulate IVD pathologies, and to promote drug development. Furthermore, the precisely targeted CRISPR/Cas9 gene therapy holds promise for the effective and targeted treatment of degenerative disc disease and low back pain. In this perspective, we pr ...[more]