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A Revised Modular Approach to (-)-trans-Δ⁸-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions.

ABSTRACT: A revised modular approach to various synthetic (-)-trans-Δ⁸-THC derivatives through late-stage Suzuki-Miyaura cross-coupling reactions is disclosed. Ten derivatives were synthesized allowing both sp²- and sp³-hybridized cross-coupling partners with minimal β-hydride elimination. Importantly, we demonstrate that a para-bromo-substituted THC scaffold for Suzuki-Miyaura cross-coupling reactions has been initially reported incorrectly in recent literature.

SUBMITTER: Bloemendal VRLJ

PROVIDER: S-EPMC6686972 | biostudies-literature |

REPOSITORIES: biostudies-literature

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