Ontology highlight
ABSTRACT:
SUBMITTER: Lopez C
PROVIDER: S-EPMC6689000 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
López Carolina C Ayala Juan A JA Bonomo Robert A RA González Lisandro J LJ Vila Alejandro J AJ
Nature communications 20190809 1
The worldwide dissemination of metallo-β-lactamases (MBLs), mediating resistance to carbapenem antibiotics, is a major public health problem. The extent of dissemination of MBLs such as VIM-2, SPM-1 and NDM among Gram-negative pathogens cannot be explained solely based on the associated mobile genetic elements or the resistance phenotype. Here, we report that MBL host range is determined by the impact of MBL expression on bacterial fitness. The signal peptide sequence of MBLs dictates their adap ...[more]