Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC6689899 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wang Hua H Fedorov Alexander A AA Fedorov Elena V EV Hunt Debbie M DM Rodgers Angela A Douglas Holly L HL Garza-Garcia Acely A Bonanno Jeffrey B JB Almo Steven C SC de Carvalho Luiz Pedro Sório LPS
Proceedings of the National Academy of Sciences of the United States of America 20190718 32
<i>Mycobacterium tuberculosis</i> (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infection, macrophages produce metabolites with the purpose of inhibiting or killing the bacterial cell. Itaconate is an abundant host metabolite thought to be both an antimicrobial agent and a modulator of the host inflammatory response. However, the exact mode ...[more]