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Crystal structure analysis of the biologically active drug mol-ecule riluzole and riluzolium chloride.


ABSTRACT: This study is an investigation into the crystal structure of the biologically active drug mol-ecule riluzole [RZ, 6-(tri-fluoro-meth-oxy)-1,3-benzo-thia-zol-2-amine], C8H5F3N2OS, and its derivative, the riluzolium chloride salt [RZHCl, 2-amino-6-(tri-fluoro-meth-oxy)-1,3-benzo-thia-zol-3-ium chloride], C8H6F3N2OS+·Cl-. In spite of repeated efforts to crystallize the drug, its crystal structure has not been reported to date, hence the current study provides a method for obtaining crystals of both riluzole and its corresponding salt, riluzolium hydro-chloride. The salt was obtained by grinding HCl with the drug and crystallizing the obtained solid from di-chloro-methane. The crystals of riluzole were obtained in the presence of l-glutamic acid and d-glutamic acid in separate experiments. In the crystal structure of RZHCl, the -OCF3 moiety is perpendicular to the mol-ecular plane containing the riluzolium ion, as can be seen by the torsion angle of 107.4?(3)°. In the case of riluzole, the torsion angles of the four different mol-ecules in the asymmetric unit show that in three cases the tri-fluoro-meth-oxy group is perpendicular to the riluzole mol-ecular plane and only in one mol-ecule does the -OCF3 group lie in the same mol-ecular plane. The crystal structure of riluzole primarily consists of strong N-H?N hydrogen bonds along with weak C-H?F, C-H?S, F?F, C?C and C?S inter-actions, while that of its salt is stabilized by strong [N-H]+?Cl- and weak C-H?Cl-, N-H?S, C-H?F, C?C, S?N and S?Cl- inter-actions.

SUBMITTER: Mondal PK 

PROVIDER: S-EPMC6690469 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Crystal structure analysis of the biologically active drug mol-ecule riluzole and riluzolium chloride.

Mondal Pradip Kumar PK   T Athulbabu A   Rao Varun V   Chopra Deepak D  

Acta crystallographica. Section E, Crystallographic communications 20190702 Pt 8


This study is an investigation into the crystal structure of the biologically active drug mol-ecule riluzole [RZ, 6-(tri-fluoro-meth-oxy)-1,3-benzo-thia-zol-2-amine], C<sub>8</sub>H<sub>5</sub>F<sub>3</sub>N<sub>2</sub>OS, and its derivative, the riluzolium chloride salt [RZHCl, 2-amino-6-(tri-fluoro-meth-oxy)-1,3-benzo-thia-zol-3-ium chloride], C<sub>8</sub>H<sub>6</sub>F<sub>3</sub>N<sub>2</sub>OS<sup>+</sup>·Cl<sup>-</sup>. In spite of repeated efforts to crystallize the drug, its crystal str  ...[more]

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