How a purine salvage enzyme singles out the right base.
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ABSTRACT:
SUBMITTER: Nagappa LK
PROVIDER: S-EPMC6690690 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
How a purine salvage enzyme singles out the right base.
Nagappa Lakshmeesha Kempaiah LK Balasubramanian Sundaram S Balaram Hemalatha H
The Journal of biological chemistry 20190801 32
Two phosphoribosyltransferases in the purine salvage pathway exhibit exquisite substrate specificity despite the chemical similarity of their distinct substrates, but the basis for this discrimination was not fully understood. Ozeir <i>et al.</i> now employ a complementary biochemical, structural, and computational approach to deduce the chemical constraints governing binding and propose a distinct mechanism for catalysis in one of these enzymes, adenine phosphoribosyltransferase. These insights ...[more]
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