Ontology highlight
ABSTRACT:
SUBMITTER: Luck H
PROVIDER: S-EPMC6692361 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Luck Helen H Khan Saad S Kim Justin H JH Copeland Julia K JK Revelo Xavier S XS Tsai Sue S Chakraborty Mainak M Cheng Kathleen K Tao Chan Yi Y Nøhr Mark K MK Clemente-Casares Xavier X Perry Marie-Christine MC Ghazarian Magar M Lei Helena H Lin Yi-Hsuan YH Coburn Bryan B Okrainec Allan A Jackson Timothy T Poutanen Susan S Gaisano Herbert H Allard Johane P JP Guttman David S DS Conner Margaret E ME Winer Shawn S Winer Daniel A DA
Nature communications 20190813 1
The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of intestinal B cells in this context is unclear. Here, we show that high fat diet (HFD) feeding alters intestinal IgA<sup>+</sup> immune cells and that IgA is a critical immune regulator of glucose homeostasis. Obese mice have fewer IgA<sup>+</sup> immune cells and less secretory IgA and IgA-promoting immune mediators. HFD-fed IgA-deficient mice have dysfunctional glucose met ...[more]