Ontology highlight
ABSTRACT:
SUBMITTER: Wara AK
PROVIDER: S-EPMC7816773 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Wara Akm Khyrul AK Wang Shijia S Wu Chun C Fang Fang F Haemmig Stefan S Weber Brittany N BN Aydogan Ceren O CO Tesmenitsky Yevgenia Y Aliakbarian Hassan H Hawse John R JR Subramaniam Malayannan M Zhao Lei L Sage Peter T PT Tavakkoli Ali A Garza Amanda A Lynch Lydia L Banks Alexander S AS Feinberg Mark W MW
Cell reports 20201201 13
CD4<sup>+</sup> T cells regulate inflammation and metabolism in obesity. An imbalance of CD4<sup>+</sup> T regulatory cells (Tregs) is critical in the development of insulin resistance and diabetes. Although cytokine control of this process is well understood, transcriptional regulation is not. KLF10, a member of the Kruppel-like transcription factor family, is an emerging regulator of immune cell function. We generated CD4<sup>+</sup>-T-cell-specific KLF10 knockout (TKO) mice and identified a p ...[more]