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Photodimerization systems for regulating protein-protein interactions with light.


ABSTRACT: Optogenetic dimerizers are modular domains that can be utilized in a variety of versatile ways to modulate cellular biochemistry. Because of their modularity, many applications using these tools can be easily transferred to new targets without extensive engineering. While a number of photodimerizer systems are currently available, the field remains nascent, with new optimizations for existing systems and new approaches to regulating biological function continuing to be introduced at a steady pace.

SUBMITTER: Spiltoir JI 

PROVIDER: S-EPMC6697570 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Photodimerization systems for regulating protein-protein interactions with light.

Spiltoir Jessica I JI   Tucker Chandra L CL  

Current opinion in structural biology 20190225


Optogenetic dimerizers are modular domains that can be utilized in a variety of versatile ways to modulate cellular biochemistry. Because of their modularity, many applications using these tools can be easily transferred to new targets without extensive engineering. While a number of photodimerizer systems are currently available, the field remains nascent, with new optimizations for existing systems and new approaches to regulating biological function continuing to be introduced at a steady pac  ...[more]

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