Ontology highlight
ABSTRACT:
SUBMITTER: Brezgin S
PROVIDER: S-EPMC7557733 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Brezgin Sergey S Kostyusheva Anastasiya A Ponomareva Natalia N Volia Viktoriia V Goptar Irina I Nikiforova Anastasiya A Shilovskiy Igor I Smirnov Valery V Kostyushev Dmitry D Chulanov Vladimir V
International journal of molecular sciences 20200918 18
Restriction of foreign DNA is a fundamental defense mechanism required for maintaining genomic stability and proper function of mammalian cells. APOBEC cytidine deaminases are crucial effector molecules involved in clearing pathogenic DNA of viruses and other microorganisms and improperly localized self-DNA (DNA leakages). Mastering the expression of APOBEC provides the crucial means both for developing novel therapeutic approaches for combating infectious and non-infectious diseases and for num ...[more]