Ontology highlight
ABSTRACT:
SUBMITTER: He L
PROVIDER: S-EPMC6700604 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
He Liang L Beghi Florian F Baral Viviane V Dépond Mallorie M Zhang Yanyan Y Joulin Virginie V Rueda Bo R BR Gonin Patrick P Foudi Adlen A Wittner Monika M Louache Fawzia F
Stem cell reports 20190718 2
Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle inhibitors. Here, we demonstrate that the adapter protein CABLES1 is a key regulator of long-term hematopoietic homeostasis during stress and aging. Young mice lacking Cables1 displayed hyperproliferation of hematopoietic progenitor cells. This defect was cell intrinsic, since it was reproduced in BM transplantation assays using wild-type animals a ...[more]