Ontology highlight
ABSTRACT:
SUBMITTER: Wan C
PROVIDER: S-EPMC8520731 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Wan Chun C Crisman Lauren L Wang Bing B Tian Yuan Y Wang Shifeng S Yang Rui R Datta Ishara I Nomura Toshifumi T Li Suzhao S Yu Haijia H Yin Qian Q Shen Jingshi J
Journal of cell science 20211005 19
Multimeric cargo adaptors such as AP2 play central roles in intracellular membrane trafficking. We recently discovered that the assembly of the AP2 adaptor complex, a key player in clathrin-mediated endocytosis, is a highly organized process controlled by alpha- and gamma-adaptin-binding protein (AAGAB, also known as p34). In this study, we demonstrate that besides AP2, AAGAB also regulates the assembly of AP1, a cargo adaptor involved in clathrin-mediated transport between the trans-Golgi netwo ...[more]