Imprint of assortative mating on the human genome.
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ABSTRACT:
SUBMITTER: Yengo L
PROVIDER: S-EPMC6705135 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Imprint of assortative mating on the human genome.
Yengo Loic L Robinson Matthew R MR Keller Matthew C MC Kemper Kathryn E KE Yang Yuanhao Y Trzaskowski Maciej M Gratten Jacob J Turley Patrick P Cesarini David D Benjamin Daniel J DJ Wray Naomi R NR Goddard Michael E ME Yang Jian J Visscher Peter M PM
Nature human behaviour 20181126 12
Preference for mates with similar phenotypes; that is, assortative mating, is widely observed in humans<sup>1-5</sup> and has evolutionary consequences<sup>6-8</sup>. Under Fisher's classical theory<sup>6</sup>, assortative mating is predicted to induce a signature in the genome at trait-associated loci that can be detected and quantified. Here, we develop and apply a method to quantify assortative mating on a specific trait by estimating the correlation (θ) between genetic predictors of the tra ...[more]
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