Ontology highlight
ABSTRACT:
SUBMITTER: Brimblecombe KR
PROVIDER: S-EPMC6706870 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Brimblecombe Katherine R KR Vietti-Michelina Stefania S Platt Nicola J NJ Kastli Rahel R Hnieno Ahmad A Gracie Caitlin J CJ Cragg Stephanie J SJ
ACS chemical neuroscience 20190805 8
The calcium-binding protein calbindin-D28K, or calb1, is expressed at higher levels by dopamine (DA) neurons originating in the ventral tegmental area (VTA) than in the adjacent substantia nigra pars compacta (SNc). Calb1 has received attention for a potential role in neuroprotection in Parkinson's disease. The underlying physiological roles for calb1 are incompletely understood. We used cre-loxP technology to knock down calb1 in mouse DA neurons to test whether calb1 governs axonal release of D ...[more]