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Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.

ABSTRACT: Due to intrinsic multidrug resistance, pulmonary infections with Mycobacterium abscessus are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against Mycobacterium abscessus both in vitro and in vivo Here, we report that verapamil improves the efficacy of bedaquiline activity against M. abscessus clinical isolates and low-level resistant strains, both in vitro and in macrophages. Verapamil may have clinical potential as adjunctive therapy provided that sufficiently high doses can be safely achieved.

SUBMITTER: Viljoen A

PROVIDER: S-EPMC6709475 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.

Viljoen Albertus A Raynaud Clément C Johansen Matt D MD Roquet-Banères Françoise F Herrmann Jean-Louis JL Daher Wassim W Kremer Laurent L

Antimicrobial agents and chemotherapy 20190823 9

Due to intrinsic multidrug resistance, pulmonary infections with Mycobacterium abscessus are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against Mycobacterium abscessus both in vitro and in vivo Here, we report that verapamil improves the efficacy of bedaquiline activity against M. abscessus clinical isolates and low-level resistant strains, both in vitro and in macrophages. Verapamil may have clinical p ...[more]

PMID: 31209005

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Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus.

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In Vitro Activity of Bedaquiline and Imipenem against Actively Growing, Nutrient-Starved, and Intracellular Mycobacterium abscessus.

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