Genome-wide association study for proliferative diabetic retinopathy in Africans.

ABSTRACT: Proliferative diabetic retinopathy (PDR) is a sight-threatening complication of diabetes that is associated with longer duration of diabetes and poor glycemic control under a genetic susceptibility background. Although GWAS of PDR have been conducted in Europeans and Asians, none has been done in continental Africans, a population at increased risk for PDR. Here, we report a GWAS of PDR among Africans. PDR cases (n?=?64) were T2D patients with neovascularization in the retina and/or retinal detachment. Controls (n?=?227) were T2D patients without listed eye complications despite high risk (T2D duration ?10 years and fasting blood glucose >169?mg/dl). Replication was assessed in African Americans enrolled in the ARIC study. We identified 4 significant loci: WDR72, HLA-B, GAP43/RP11-326J18.1, and AL713866.1. At WDR72 the most strongly associated SNPs were rs12906891 (MAF?=?0.071; p?=?9.68?×?10-10; OR?=?1.46, 95% CI [1.30,1.64]) and rs11070992 (MAF?=?0.14; p?=?4.23?×?10-8; OR?=?1.28, 95%CI [1.17-1.40]). rs11070992 replicated in African Americans (p?=?0.04). Variants in this gene have been associated with diabetic retinopathy, glycemic control, revascularization, and kidney disease.

SUBMITTER: Liu C 

PROVIDER: S-EPMC6715701 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature