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Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.

ABSTRACT: BACKGROUND:Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-?1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, -509C/T (rs1800469), codon 10?T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection. METHODS:The summary odds ratios (ORs) of chronic HCV infected patients and controls with all SNPs were obtained by adaptive fixed or random effect model. A series of statistical tools were employed to guarantee the accuracy of related pooling ORs, including the Hardy-Weinberg equilibrium (HWE) test, sensitivity analysis and publication bias test. RESULTS:This paper analyzed 18 case-control studies in 17 articles which totally contains 2718 chronic HCV infection cases corresponding to 1964 controls. The results of the meta-analysis indicated that the -509C/T polymorphism effected an increased risk of chronic HCV infection in all gene models. More specifically by ethnicity stratification, the Egyptians shared the similar association with the above overall study. Moreover, the meta-fusion of healthy control studies showed that -?509?T allele carriers (TT?+?TA) had nearly 2.00 and 3.36 fold higher risk of chronic HCV infection in the total and Egyptian populations, respectively (OR?=?2.004, 95% CI?=?1.138-3.528, P =?0.016; OR?=?3.363, 95% CI?=?1.477-7.655, P =?0.004, respectively). However, our meta-analysis did not find any significant association between the codon 10?T/C or codon 25G/C polymorphisms and chronic HCV infection. CONCLUSIONS:Our results suggested that the TGF-ß1-509C/T polymorphism may effect an increased risk of chronic HCV infection, especially in Egyptian population.

SUBMITTER: Guo P

PROVIDER: S-EPMC6716859 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.

Guo Pengfei P Liu Shuangyin S Sun Xiangru X Xu Longqin L

BMC infectious diseases 20190830 1

<h4>Background</h4>Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, -509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection.<h4>Methods</h4>The summary odd ...[more]

PMID: 31470810

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Project description:ObjectiveThe objective of this study is to investigate the association between toll-like receptor (TLR) 3/7 gene polymorphisms and the infection by hepatitis C virus (HCV).MethodsPubMed, Embase, Web of Science, Scopus, CNKI, Wanfang Data, and SinoMed were searched to identify studies focusing on the association between the TLR3 rs3775290 or the TLR7 rs179008 single nucleotide polymorphisms (SNPs) and the HCV infection. All the related articles were collected from the inception of each database to 15 January 2023. Our meta-analysis was conducted using the allelic model, the dominant model, and the recessive model. Outcomes were presented by odds ratio (ORs) and 95% confidence interval (95%CI). The heterogeneity across studies was assessed by the I2 test. A subgroup analysis was performed to explore the source of heterogeneity. Funnel plots were drawn to assess the risk of publication bias. Review Manager 5.4 was used for statistical analysis.ResultsTen articles were finally included, among which six studies were analyzed for rs3775290 and five studies were analyzed for rs179008. Studies relating to rs3775290 included 801 patients and 1,045 controls, whereas studies relating to rs179008 included 924 patients and 784 controls. The results of the meta-analysis showed that there is no significant association between rs3775290 gene polymorphism and HCV infection (T vs. C: OR = 1.12, 95%CI 0.97-1.30; TT+CT vs. CC: OR = 1.20, 95%CI 0.73-1.96; TT vs. CT+CC: OR = 1.13, 95%CI 0.68-1.89). The recessive model showed that rs179008-T allele homozygotes had an 89% increased risk of infection by HCV compared with rs179008-A allele carriers (TT vs. AT+AA: OR = 1.89, 95%CI 1.13-3.16). The results of the subgroup analysis demonstrated that the characteristics of the control population may serve as an important source of heterogeneity. In the African populations, individuals with homozygous rs179008-T alleles had a higher risk of infection by HCV than rs179008-A allele carriers (OR = 2.14, 95%CI 1.18-3.87). We did not find that this difference existed in the European populations (OR = 1.24, 95%CI 0.43-3.56).ConclusionThere is no significant association between rs3775290 single nucleotide polymorphism and the infection by HCV. Individuals with homozygous rs179008-T alleles have a higher risk of an infection by HCV than rs179008-A allele carriers, which is statistically significant in the African populations.

Dataset Information

Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.

Publications

Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.

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