Ontology highlight
ABSTRACT:
SUBMITTER: Bothwell IR
PROVIDER: S-EPMC6717260 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Bothwell Ian R IR Cogan Dillon P DP Kim Terry T Reinhardt Christopher J CJ van der Donk Wilfred A WA Nair Satish K SK
Proceedings of the National Academy of Sciences of the United States of America 20190813 35
The peptide natural product nisin has been used as a food preservative for 6 decades with minimal development of resistance. Nisin contains the unusual amino acids dehydroalanine and dehydrobutyrine, which are posttranslationally installed by class I lanthipeptide dehydratases (LanBs) on a linear peptide substrate through an unusual glutamyl-tRNA-dependent dehydration of Ser and Thr. To date, little is known about how LanBs catalyze the transfer of glutamate from charged tRNA<sup>Glu</sup> to th ...[more]