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Glutamyl Endopeptidases: The Puzzle of Substrate Specificity.

ABSTRACT: Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the ?-carboxyl groups of glutamic acid. Despite the many years of research, the structural determinants underlying the strong substrate specificity of GEPases still remain unclear. In this review, data concerning the molecular mechanisms that determine the substrate preference of GEPases is generalized. In addition, the biological functions of and modern trends in the research into these enzymes are outlined.

SUBMITTER: Demidyuk IV

PROVIDER: S-EPMC5508998 | biostudies-literature | 2017 Apr-Jun

REPOSITORIES: biostudies-literature

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Glutamyl Endopeptidases: The Puzzle of Substrate Specificity.

Demidyuk I V IV Chukhontseva K N KN Kostrov S V SV

Acta naturae 20170401 2

Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the α-carboxyl groups of glutamic acid. Despite the many years of research, the structural determinants underlying the strong substrate specificity of GEPases still remain unclear. In this review, data concerning the molecular mechanisms that determine the substrate preference of GEPases is generalized. In addition, the biological functions of and modern trends in the research into the ...[more]

PMID: 28740724

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