Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki SW
PROVIDER: S-EPMC6719449 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Suzuki Sho W SW Chuang Ya-Shan YS Li Ming M Seaman Matthew N J MNJ Emr Scott D SD
The Journal of cell biology 20190723 9
Retromer is an evolutionarily conserved protein complex, which sorts functionally diverse membrane proteins into recycling tubules/vesicles from the endosome. Many of the identified cargos possess a recycling signal sequence defined as ØX[L/M/V], where Ø is F/Y/W. However, this sequence is present in almost all proteins encoded in the genome. Also, several identified recycling sequences do not follow this rule. How then does retromer precisely select its cargos? Here, we reveal that an additiona ...[more]