Ontology highlight
ABSTRACT:
SUBMITTER: Smolle E
PROVIDER: S-EPMC6721451 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Smolle Elisabeth E Fink-Neuboeck Nicole N Lindenmann Joerg J Smolle-Juettner Freyja F Pichler Martin M
Cancers 20190806 8
Carcinogenic mutations allow cells to escape governing mechanisms that commonly inhibit uncontrolled cell proliferation and maintain tightly regulated homeostasis between cell death and survival. Members of the inhibition of growth (ING) family act as tumor suppressors, governing cell cycle, apoptosis and cellular senescence. The molecular mechanism of action of <i>ING</i> genes, as well as their anchor points in pathways commonly linked to malignant transformation of cells, have been studied wi ...[more]