Ontology highlight
ABSTRACT:
SUBMITTER: Syed SN
PROVIDER: S-EPMC6721555 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Syed Shahzad Nawaz SN Raue Rebecca R Weigert Andreas A von Knethen Andreas A Brüne Bernhard B
Cells 20190728 8
The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammation remains unknown. We show that myeloid specific S1P receptor 1 (S1PR1) deletion enhances early inflammation in a mouse model of imiquimod-induced psoriasis, without altering the i ...[more]