Ontology highlight
ABSTRACT:
SUBMITTER: Jabalera Y
PROVIDER: S-EPMC6723246 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Jabalera Ylenia Y Garcia-Pinel Beatriz B Ortiz Raul R Iglesias Guillermo G Cabeza Laura L Prados José J Jimenez-Lopez Concepcion C Melguizo Consolación C
Pharmaceutics 20190806 8
Conventional chemotherapy against colorectal cancer (CRC), the third most common cancer in the world, includes oxaliplatin (Oxa) which induces serious unwanted side effects that limit the efficiency of treatment. Therefore, alternative therapeutic approaches are urgently required. In this work, biomimetic magnetic nanoparticles (BMNPs) mediated by MamC were coupled to Oxa to evaluate the potential of the Oxa-BMNP nanoassembly for directed local delivery of the drug as a proof of concept for the ...[more]