Ontology highlight
ABSTRACT:
SUBMITTER: Cunningham C
PROVIDER: S-EPMC6725757 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Cunningham Colm C Wilcockson David C DC Campion Suzanne S Lunnon Katie K Perry V Hugh VH
The Journal of neuroscience : the official journal of the Society for Neuroscience 20051001 40
The contribution of inflammation to the progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, and prion diseases is poorly understood. Brain inflammation in animal models of these diseases is dominated by chronic microglial activation with minimal proinflammatory cytokine expression. However, these inflammatory cells are "primed" to produce exaggerated inflammatory responses to subsequent lipopolysaccharide (LPS) challenges. We show that, using the ME7 model of prion diseas ...[more]