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Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.

ABSTRACT: Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome-wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (ANYDEP) among 7291 European-Americans (EA; 2927 cases) and 3132 African-Americans (AA: 1315 cases) participating in the family-based Collaborative Study on the Genetics of Alcoholism. ANYDEP was heritable (h 2 in EA = 0.60, AA = 0.37). The AA GWAS identified three regions with genome-wide significant (GWS; P?

SUBMITTER: Wetherill L 

PROVIDER: S-EPMC6726116 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.

Wetherill Leah L   Lai Dongbing D   Johnson Emma C EC   Anokhin Andrey A   Bauer Lance L   Bucholz Kathleen K KK   Dick Danielle M DM   Hariri Ahmad R AR   Hesselbrock Victor V   Kamarajan Chella C   Kramer John J   Kuperman Samuel S   Meyers Jacquelyn L JL   Nurnberger John I JI   Schuckit Marc M   Scott Denise M DM   Taylor Robert E RE   Tischfield Jay J   Porjesz Bernice B   Goate Alison M AM   Edenberg Howard J HJ   Foroud Tatiana T   Bogdan Ryan R   Agrawal Arpana A  

Genes, brain, and behavior 20190611 6

Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome-wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (ANYDEP) among 7291 European-Americans (EA; 2927 cases) and 3132 African-Americans (AA: 1315 cases) participating in the family-based Collaborative Study on the Genetics of Alcoholism. ANYDEP was heritable (h <sup>2</sup> in EA = 0.60, AA = 0.37). The A  ...[more]

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