FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.
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ABSTRACT:
SUBMITTER: Hahle A
PROVIDER: S-EPMC6730887 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.
Hähle Andreas A Geiger Thomas M TM Merz Stephanie S Meyners Christian C Tianqi Mao M Kolos Jürgen J Hausch Felix F
PloS one 20190906 9
The protein factor Glomulin (Glmn) is a regulator of the SCF (Skp1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Mutations of Glmn lead to glomuvenous malformations. Glmn has been reported to be associated with FK506-binding proteins (FKBP). Here we present in vitro binding analyses of the FKBP-Glmn interaction. Interestingly, the previously described interaction of Glmn and FKBP12 was found to be comparatively weak. Instead, the closely related FKBP12.6 and FKBP51 emerged as novel bi ...[more]
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