Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Q
PROVIDER: S-EPMC6731067 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Chemistry (Weinheim an der Bergstrasse, Germany) 20190726 46
In this report, a palladium-catalyzed redox-relay Heck process to access optically active alkenylated α,β-unsaturated lactams is described. Under mild reaction conditions, electron-deficient alkenyl triflates and electron-rich alkenyl iodonium salts undergo enantioselective and site-selective coupling with enelactams to deliver the products in high yields and excellent enantioselectivities. Furthermore, the products allow facile access to natural products such as (+)-calvine and (+)-2-epicalvine ...[more]