Ontology highlight
ABSTRACT:
SUBMITTER: Thuveson M
PROVIDER: S-EPMC6731590 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Thuveson Maria M Gaengel Konstantin K Collu Giovanna M GM Chin Mei-Ling ML Singh Jaskirat J Mlodzik Marek M
Open biology 20190814 8
Integrins mediate the anchorage between cells and their environment, the extracellular matrix (ECM), and form transmembrane links between the ECM and the cytoskeleton, a conserved feature throughout development and morphogenesis of epithelial organs. Here, we demonstrate that integrins and components of the ECM are required during the planar cell polarity (PCP) signalling-regulated cell movement of ommatidial rotation in the Drosophila eye. The loss-of-function mutations of integrins or ECM comp ...[more]