Ontology highlight
ABSTRACT:
SUBMITTER: Demetriou E
PROVIDER: S-EPMC6734798 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Demetriou Eleni E Story Harriet E HE Bofinger Robin R Hailes Helen C HC Tabor Alethea B AB Golay Xavier X
The journal of physical chemistry. B 20190826 35
Exogenous chemical exchange saturation transfer (CEST) contrast agents such as glucose or 2-deoxy-d-glucose (2-DG) have shown high sensitivities and significant potential for monitoring glucose uptake in tumors with MRI. Here, we show that liposome encapsulation of such agents can be exploited to enhance the CEST signal by reducing the overall apparent exchange rate. We have developed a concise analytical model to describe the liposomal contrast dependence on several parameters such as pH, tempe ...[more]