Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma.
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ABSTRACT:
SUBMITTER: Lam JH
PROVIDER: S-EPMC6738266 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma.
Lam Jian Hang JH Ng Harry Ho Man HHM Lim Chun Jye CJ Sim Xin Ni XN Malavasi Fabio F Li Huihua H Loh Josh Jie Hua JJH Sabai Khin K Kim Joo-Kyung JK Ong Clara Chong Hui CCH Loh Tracy T Leow Wei Qiang WQ Choo Su Pin SP Toh Han Chong HC Lee Ser Yee SY Chan Chung Yip CY Chew Valerie V Lim Tong Seng TS Yeong Joe J Lim Tony Kiat Hon TKH
Frontiers in immunology 20190904
<b>Background:</b> CD38 is involved in the adenosine pathway, which represents one of the immunosuppressive mechanisms in cancer. CD38 is broadly expressed across immune cell subsets, including human macrophages differentiated <i>in vitro</i> from monocytes, but expression by tissue-resident macrophages remains to be demonstrated. <b>Methods:</b> Tissue samples were obtained from 66 patients with hepatocellular carcinoma (HCC) from Singapore and analyzed using immunohistochemistry. Tumor-infiltr ...[more]
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