Ontology highlight
ABSTRACT:
SUBMITTER: Xie X
PROVIDER: S-EPMC6739626 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Xie Xiujie X Urabe Go G Marcho Lynn L Stratton Matthew M Guo Lian-Wang LW Kent Craig K CK
iScience 20190827
Vascular smooth muscle cell (VSMC) proliferation promotes intimal hyperplasia (IH) in occluding vascular diseases. Here we identified a positive role of ALDH1A3 (an aldehyde dehydrogenase) in this pro-IH process. The expression of ALDH1A3, but not that of 18 other isoforms of the ALDH family, was substantially increased in cytokine-stimulated VSMCs. PDGF(BB) stimulated VSMC total ALDH activity and proliferation, whereas ALDH1A3 silencing abolished this effect. ALDH1A3 silencing also diminished t ...[more]