Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC6742228 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wang Wei W Vassell Russell R Song Hyo Sook HS Chen Qiong Q Keller Paul W PW Verma Swati S Alvarado-Facundo Esmeralda E Wan Hongquan H Schmeisser Falko F Meseda Clement A CA Weir Jerry P JP Weiss Carol D CD
PloS one 20190912 9
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across multiple years. However, efficient induction of cross-neutralizing antibodies remains a challenge, and potential escape mutations have not been well characterized. Here we elicited cross-neutralizing antibodies by immunizing animals with the hemagglutini ...[more]