Dataset Information

Glioblastoma and Anaplastic Astrocytoma: Differentiation Using MRI Texture Analysis.

ABSTRACT: Introduction: Glioblastoma and anaplastic astrocytoma (ANA) are two of the most common primary brain tumors in adults. The differential diagnosis is important for treatment recommendations and prognosis assessment. This study aimed to assess the discriminative ability of texture analysis using machine learning to distinguish glioblastoma from ANA. Methods: A total of 123 patients with glioblastoma (n = 76) or ANA (n = 47) were enrolled in this study. Texture features were extracted from contrast-enhanced Magnetic Resonance (MR) images using LifeX package. Three independent feature-selection methods were performed to select the most discriminating parameters:Distance Correlation, least absolute shrinkage and selection operator (LASSO), and gradient correlation decision tree (GBDT). These selected features (datasets) were then randomly split into the training and the validation group at the ratio of 4:1 and were fed into linear discriminant analysis (LDA), respectively, and independently. The standard sensitivity, specificity, the areas under receiver operating characteristic curve (AUC) and accuracy were calculated for both training and validation group. Results: All three models (Distance Correlation + LDA, LASSO + LDA and GBDT + LDA) showed promising ability to discriminate glioblastoma from ANA, with AUCs ?0.95 for both the training and the validation group using LDA algorithm and no overfitting was observed. LASSO + LDA showed the best discriminative ability in horizontal comparison among three models. Conclusion: Our study shows that MRI texture analysis using LDA algorithm had promising ability to discriminate glioblastoma from ANA. Multi-center studies with greater number of patients are warranted in future studies to confirm the preliminary result.

SUBMITTER: Tian Z

PROVIDER: S-EPMC6743014 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Glioblastoma and Anaplastic Astrocytoma: Differentiation Using MRI Texture Analysis.

Tian Zerong Z Chen Chaoyue C Fan Yimeng Y Ou Xuejin X Wang Jian J Ma Xuelei X Xu Jianguo J

Frontiers in oncology 20190906

Introduction: Glioblastoma and anaplastic astrocytoma (ANA) are two of the most common primary brain tumors in adults. The differential diagnosis is important for treatment recommendations and prognosis assessment. This study aimed to assess the discriminative ability of texture analysis using machine learning to distinguish glioblastoma from ANA. Methods: A total of 123 patients with glioblastoma (n = 76) or ANA (n = 47) were enrolled in this study. Texture features ...[more]

PMID: 31552189

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Project description:Anaplastic astrocytoma (AA) and its more aggressive counterpart, glioblastoma multiforme (GBM), are the most common intrinsic brain tumors in adults and are almost universally fatal. A deeper understanding of the molecular relationship of these tumor types is necessary to derive insights into the diagnosis, prognosis, and treatment of gliomas. Although genomewide profiling of expression levels with microarrays can be used to identify differentially expressed genes between these tumor types, comparative studies so far have resulted in gene lists that show little overlap.To achieve a more accurate and stable list of the differentially expressed genes and pathways between primary GBM and AA, we performed a meta-analysis using publicly available genome-scale mRNA data sets. There were four data sets with sufficiently large sample sizes of both GBMs and AAs, all of which coincidentally used human U133 platforms from Affymetrix, allowing for easier and more precise integration of data. After scoring genes and pathways within each data set, we combined the statistics across studies using the nonparametric rank sum method to identify the features that differentiate GBMs and AAs. We found >900 statistically significant probe sets after correction for multiple testing from the >22,000 tested. We also used the rank sum approach to select >20 significant Biocarta pathways after correction for multiple testing out of >175 pathways examined. The most significant pathway was the hypoxia-inducible factor (HIF) pathway. Our analysis suggests that many of the most statistically significant genes work together in a HIF1A/VEGF-regulated network to increase angiogenesis and invasion in GBM when compared to AA.We have performed a meta-analysis of genome-scale mRNA expression data for 289 human malignant gliomas and have identified a list of >900 probe sets and >20 pathways that are significantly different between GBM and AA. These feature lists could be utilized to aid in diagnosis, prognosis, and grade reduction of high-grade gliomas and to identify genes that were not previously suspected of playing an important role in glioma biology. More generally, this approach suggests that combined analysis of existing data sets can reveal new insights and that the large amount of publicly available cancer data sets should be further utilized in a similar manner.

Project description:Purpose:To find potentially diagnostic texture analysis (TA) features and to evaluate the diagnostic accuracy of two-dimensional (2D) magnetic resonance (MR) TA for differentiation between hepatocellular carcinoma (HCC) and benign hepatocellular tumors in the non-cirrhotic liver in an exploratory MR-study. Materials and methods:108 non-cirrhotic patients (62 female; 41.5 ± 18.3 years) undergoing preoperative contrast-enhanced MRI were retrospectively included in this multi-center-study. TA including gray-level histogram, co-occurrence and run-length matrix features (total 19 features) was performed by two independent readers. Native fat-saturated-T1w and T2w as well as arterial and portal-venous post contrast-enhanced 2D-image-slices were assessed. Conventional reading was performed by two separate independent readers. Differences in TA features between HCC and benign lesions were investigated using independent sample t-tests. Logistic regression analysis was performed to obtain the optimal number/combination of TA-features and diagnostic accuracy of TA analysis. Sensitivity and specificity of the better performing radiologist were compared to TA analysis. Results:The highest number of significantly differing TA-features (n = 5) was found using the arterial-phase images including one gray-level histogram (skewness, p = 0.018) and four run-length matrix features (all, p < 0.02). The optimal binary logistic regression model for TA-features of the arterial-phase images contained 13 parameters with an accuracy of 84.5% (sensitivity 84.1%, specificity 84.9%) and area-under-the-curve of 0.92 (95%-confidence-interval 0.85-0.98) for diagnosis of HCC. Conventional reading yielded a significantly lower sensitivity (63.6%, p = 0.027) and no significant difference in specificity (94.6%, p = 0.289) at best. Conclusion:2D-TA of MR images is a feasible objective method that may help to distinguish HCC from benign hepatocellular tumors in the non-cirrhotic liver. Most promising results were found in TA features in the arterial phase images.

Dataset Information

Glioblastoma and Anaplastic Astrocytoma: Differentiation Using MRI Texture Analysis.

Publications

Glioblastoma and Anaplastic Astrocytoma: Differentiation Using MRI Texture Analysis.

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