Bevacizumab and Cediranib Maleate in Treating Patients With Metastatic or Unresectable Solid Tumor, Lymphoma, Intracranial Glioblastoma, Gliosarcoma or Anaplastic Astrocytoma

ABSTRACT: This phase I trial is studying the side effects and best dose of bevacizumab and cediranib maleate in treating patients with metastatic or unresectable solid tumor, lymphoma, intracranial glioblastoma, gliosarcoma or anaplastic astrocytoma. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Cediranib maleate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Bevacizumab and cediranib maleate may also stop the growth of cancer cells by blocking blood flow to the cancer. Giving bevacizumab together with cediranib maleate may kill more cancer cells.

DISEASE(S): Recurrent Childhood Small Noncleaved Cell Lymphoma,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Adult Grade Iii Lymphomatoid Granulomatosis,Stage Iv Adult T-cell Leukemia/lymphoma,Stage Iv Adult Diffuse Large Cell Lymphoma,Lymphoma, Large-cell, Immunoblastic,Recurrent Childhood Anaplastic Large Cell Lymphoma,Stage Iva Mycosis Fungoides/sezary Syndrome,Small Intestine Lymphoma,Stage Iv Adult Diffuse Mixed Cell Lymphoma,Progressive Hairy Cell Leukemia, Initial Treatment,Neoplasms,Childhood Burkitt Lymphoma,Stage Iv Adult Immunoblastic Large Cell Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Refractory Hairy Cell Leukemia,Sezary Syndrome,T-cell Large Granular Lymphocyte Leukemia,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Leukemia, Hairy Cell,Childhood Immunoblastic Large Cell Lymphoma,Stage Ivb Mycosis Fungoides/sezary Syndrome,Mycosis Fungoides,Lymphoma, Mantle-cell,Stage Iv Adult Lymphoblastic Lymphoma,Leukemia-lymphoma, Adult T-cell,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Adult Burkitt Lymphoma,Stage Iv Grade 1 Follicular Lymphoma,Stage Iv Mantle Cell Lymphoma,Leukemia, T-cell,Lymphomatoid Granulomatosis,Recurrent Childhood Lymphoblastic Lymphoma,Lymphoma, T-cell, Peripheral,Stage Iv Childhood Small Noncleaved Cell Lymphoma,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Stage Iv Childhood Anaplastic Large Cell Lymphoma,Lymphoma, B-cell, Marginal Zone,Burkitt Lymphoma,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Stage Iv Childhood Large Cell Lymphoma,Nodal Marginal Zone B-cell Lymphoma,Childhood Diffuse Large Cell Lymphoma,Stage Iv Adult Burkitt Lymphoma,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Intraocular Lymphoma,Unspecified Childhood Solid Tumor, Protocol Specific,Recurrent Mantle Cell Lymphoma,Recurrent Grade 3 Follicular Lymphoma,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Childhood Grade Iii Lymphomatoid Granulomatosis,Waldenström Macroglobulinemia,Noncutaneous Extranodal Lymphoma,Recurrent Adult Lymphoblastic Lymphoma,Recurrent Childhood Large Cell Lymphoma,Angioimmunoblastic T-cell Lymphoma,Unspecified Adult Solid Tumor, Protocol Specific,Leukemia, Large Granular Lymphocytic,Testicular Lymphoma,Lymphoma, Large-cell, Anaplastic,Stage Iv Childhood Lymphoblastic Lymphoma,Stage Iv Adult Hodgkin Lymphoma,Lymphoma, T-cell,Hepatosplenic T-cell Lymphoma,Stage Iv Grade 3 Follicular Lymphoma,Stage Iv Adult Diffuse Small Cleaved Cell Lymphoma,Immunoblastic Lymphadenopathy,Precursor Cell Lymphoblastic Leukemia-lymphoma,Lymphoma,Childhood Nasal Type Extranodal Nk/t-cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Stage Iv Childhood Hodgkin Lymphoma,Anaplastic Large Cell Lymphoma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Peripheral T-cell Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Stage Iv Grade 2 Follicular Lymphoma,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Recurrent/refractory Childhood Hodgkin Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2038889 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR