Ontology highlight
ABSTRACT:
SUBMITTER: Kainulainen MH
PROVIDER: S-EPMC6744324 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20190901 8
Lassa fever is a frequently severe human disease that is endemic to several countries in West Africa. To date, no licensed vaccines are available to prevent Lassa virus (LASV) infection, even though Lassa fever is thought to be an important disease contributing to mortality and both acute and chronic morbidity. We have previously described a vaccine candidate composed of single-cycle LASV replicon particles (VRPs) and a stable cell line for their production. Here, we refine the genetic compositi ...[more]